A primary human pancreatic tumor line (BxPC-3) has been established from a biopsy specimen of a histologically confirmed adenocarcinoma of the body of the pancreas. Tumorigenicity was proven by xenograft in athymic nude mice. Upon re-establishment of tumor xenografts in tissue culture, the epithelial tumor cells retained their original morphology. Histopathologically, the tumors grown in nude mice exhibited the original characteristics of the primary adenocarcinoma in the patient, producing traceable mucin and displaying moderately well to poorly differentiated adenocarcinomas with occasional lymphocytic infiltrations at the tumor peripheries. Furthermore, the tumor xenografts differentially expressed carcinoembryonic antigen, human pancreas cancer-associated antigen, and human pancreas-specific antigen. Karyotyping and glucose-6-phosphate dehydrogenase isoenzyme characterization revealed that this tumor line was of human origin and devoid of HeLa cell contamination. The BxPC-3 tumor line has been maintained for more than four years in our laboratory and represents a valuable model for primary human pancreatic cancer.

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A retrospective review of upper gastrointestinal bleeding in 55 patients with malignant disease is presented here. Major causative factors seem to be superficial gastritis and gastric erosions. With aggressive endoscopy, a diagnostic accuracy of 90 percent has been achieved. However, having the exact diagnosis too often has little significance on the final outcome of these critically ill patients, unless therapy directed against bleeding can provide time for effective antineoplastic treatment. With the better understanding of the pathology of the superficial gastric erosions, a better program of management can be evolved.

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