Proteomics is a very active field driven by frequent introduction of new technological approaches, leading to high demand for new software tools and the concurrent development of many methods for data analysis, processing and storage. The rapidly changing landscape of proteomics software makes finding a tool fit for a particular purpose a significant challenge. The comparison of software and the selection of tools capable to perform a certain operation on a given type of data relies on their detailed annotation using well-defined descriptors. However, finding accurate information including tool input/output capabilities can be challenging and often heavily depends on manual curation efforts. This is further hampered by a rather low half-life of most of the tools, thus demanding the maintenance of a resource with updated information about the tools. We present here our approach to curate a collection of 189 software tools with detailed information about their functional capabilities. We furthermore describe our efforts to reach out to the proteomics community for their engagement, which further increased the catalogue to >750 tools being about 70% of the estimated number of 1,097 tools existing for proteomics data analysis. Descriptions of all annotated tools are available through https://proteomics.bio.tools

In this study an environmentally friendly synthesis of poly(pyrrole-2-carboxylic acid) (PCPy) particles dispersed in water–ethanol medium using enzymatic catalysis is proposed.

We report on the construction of functionalized nanotubes based on tail sheath protein 041 from vB_KleM-RaK2 bacteriophage. The truncated 041 protein (041Δ200) was fused with fluorescent proteins GFP and mCherry or amidohydrolase YqfB. The generated chimeric proteins were successfully synthesized in E. coli BL21 (DE3) cells and self-assembled into tubular structures. We detected the fluorescence of the structures, which was confirmed by stimulated emission depletion microscopy. When 041Δ200GFP and 041Δ200mCherry were coexpressed in E. coli BL21 (DE3) cells, the formed nanotubes generated Förster resonance energy transfer, indicating that both fluorescent proteins assemble into a single nanotube. Chimeric 041Δ200YqfB nanotubes possessed an enzymatic activity, which was confirmed by hydrolysis of N4-acetyl-2′-deoxycytidine. The enzymatic properties of 041Δ200YqfB were similar to those of a free wild-type YqfB. Hence, we conclude that 041-based chimeric nanotubes have the potential for the development of delivery vehicles and targeted imaging and are applicable as scaffolds for biocatalysts.

Dielectric response of Ba 2 NdFeNb 4-x Ta x O 15 (x 0.3, 0.6 and 2) solid solutions with Tetragonal Tungsten Bronze structure has been investigated by means of broadband dielectric spectroscopy in the frequency range from 20 Hz to 37 GHz. Pure Ba 2 NdFeNb 4 O 15 compound displays ferroelectric behavior. Substitution of Nb 5C by Ta 5C considerably alters dielectric response of this system. Ferroelectric state was observed only for x 0.3 compound with slightly lowered ferroelectric phase transition temperature. Further increase of x causes formation of relaxor state in these solid solutions and considerably lowers corresponding dielectric permittivity dispersion temperature region.

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