Background: Propofol is one of the widely used intravenousanaesthetics, although pain on injection still remains a considerable concern for the anaesthesiologists. The aim of my randomized double blinded study was to compare the effectiveness of Granisetron and Metoclopramide in reducing Propofol .1%) with mild pain (VRS 1), 20 patients (5.3%) with moderate pain (VRS 2), 14 patients (3.7%) with severe pain (VRS 3). 151 patients (39.7%) complained of pain in group pretreated with Metoclopramide that is is 76 patients (20%) with mild Pain (VRS 1), 57 patients (15%) with moderate pain (VRS 2) , 18 patients (4.7%) with severe pain (VRS 3). The presence and severity of pain was less in the Granisetron group compared withMetoclopramide group (P< 0.05