The neurovegetative response to laryngoscopy and intubation has been a critical perioperative concern. Numerous pharmacological agents, such as opioids, local anaesthetics, -blockers and agonists has been tried to attenuate the haemodynamic challenge and augment analgesia. Dexmedetomidine is an adrenoceptor, while fentanyl is a μ receptor opioid agonist, both drugs have been clinically tried in various clinical role in anaesthesia practice. They have been claimed to produce sedation, anxiolysis, hypnosis, analgesia, and sympatholysis individually. Dexmedetomidine has been further found to have opioid sparing effect while fentanyl has been used in clinical practice as a sole anaesthetic that blunts the sympathetic response during intubation. These variable characteristics of two drugsare the point of consideration in the present study to compare their effects on haemodynamic response to laryngoscopy and analgesia.