Introduction: Intra-operative complications like torrential and uncontrollable blood loss are a nightmare for most of the surgeons. Intra-operative installation of topical tranexamic acid reduces the blood loss to a greater extent and decreases the requirement of blood transfusion. The present study is intended to study the effect of topical tranexamic acid in reducing blood loss during abdominal hysterectomies. Objectives: To assess the efficacy of topical Tranexamic acid in reducing the perioperative blood loss in abdominal hysterectomy surgeries. Materials and Methods: It is a randomized double-blind placebo-controlled trial conducted in Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry. 100 women undergoing abdominal hysterectomy where randomly assigned to two groups: 50 patients received 100 ml normal saline IV served as the control group and another 50 patients who received 1 g topical tranexamic acid applied intra abdominally during hysterectomy served as the study group. The primary outcome was to assess intra-operative and postoperative blood loss. Results: The study group (topical tranexamic acid application) showed marked reduction in intra-operative and post-operative blood loss (blood in the intra-abdominal drain) compared with control group (placebo group). Conclusion: Topical Tranexamic acid application helps to prevent blood loss during and after major surgeries. It is safe drug which can be used with acceptable rate of complications. It improves postoperative morbidity and mortality