Background: Intubation in the ICU is sometimes unpredictable unlike in an operation theatre, where pre-anesthetic assessment for airway has been done. This study has been done to evaluate the usefulness of hyomental distance ratio (HMDR) in accurately predicting difficult laryngoscopy in ICU patients. Methods: In this study, 104 critically ill patients in the age group 18-70 years, undergoing tracheal intubation in ICU were included. A hard plastic ruler was pressed on the skin surface just above the hyoid bone and the distance to the tip of the anterior-most part of the mentum measured was defined as hyomental distance (HMD). HMD was assessed in neutral and extended head positions, and the HMDR was calculated. All patients were sedated, pre-oxygenated, induced, and relaxed prior to glottic visualization by direct laryngoscopy, which was performed by an experienced anesthetist. Cormack-Lehane's (CL's) grade was assessed without external laryngeal manipulation. Further management was as per ICU protocol. Results: Using the Chi-Square test for statistical analysis, a p-value of HMDR in assessing difficult laryngoscopy was found to be <0.001 suggesting strong significance. HMD in the extended head position (HDMe) showed moderate significance with a p-value of 0.047. HMDR <1.2 can be considered a clinically reliable individual predictor of difficult laryngoscopy in ICU patients. Conclusion: HMDR <1.2 can be used as a simple, easy, and reliable bedside test to predict difficult laryngoscopy amongst ICU patients. An optimal combination of tests is suggested if feasible for better accuracy.