A series of novel bis-thiazolidinone derivatives 3(a-j) have been synthesized by the cyclization of thiosemicarbazones 2(a-j) with chloroacetic acid and sodium acetate. The integrated heterocyclic compounds were featured by chemical and spectroscopic methods such as IR, 1H NMR and 13C NMR. All the synthesized compounds have been screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria such as Staphylococcus Aureus, Bacillus licheniformis, Klebsiella pneumoniae, Esherichia coli and antifungal activity against Aspergillus niger and in vitro cytotoxic activity against human cancer cell line (HeLa cell) and Vero cell line, using MTT assays but showed no activity.

Background: Reconstruction of soft tissue defects in fingers is a challenging problem and continues to evolve. A variety of flaps for reconstructing small-to-moderate defects have been described, but none is beyond drawbacks. The purpose of this study is to report and to evaluate the efficacy of the use of dorsal digital island flaps (DDIF) for the reconstruction of finger defects. Materials and Methods: The study was conducted from January 2020 to September 2021 in the Burn and Plastic Surgery Department at Rajshahi Medical College Hospital. A total of 10 DDIF, based on either proximally or distally, were done in 9 patients. Most of the causes of defects were electrical burns. All flaps survived with minimal complications to the donor finger. Results: Among 10 digits, the mean defect size was 4.24 (±2.34) cm2, ranging from 1.92 to 5.95 cm2. Defects were observed: 4 in middle fingers, 3 in thumb, 2 in ring fingers, and one in index finger. 6 fingers were in right hand. DDIF covered the defects on volar (5 cases), dorsal (4 cases), and both (1 case) surfaces. According to site, one case had defect on proximal phalanx with 3rd web space, 4 instances had on proximal phalanx, defect involving on both proximal and middle phalanx was in one case and rest 4 cases had defect on distal phalanx. Among 10 DDIF, 7 (70%) flaps were survived without any loss. Rest 3 (30%) cases had marginal necrosis (less than 2 mm loss) but did not require further procedure. Conclusion: DDIF is a reliable and effective option for finger defect coverage.

Background: A displaced supracondylar fracture in children presents a severe degree of injury often associated with potential neurovascular complications. We conducted this study to assess the functional and radiological outcome and complications of supracondylar fractures Gartland type III treated with closed manipulation and Kirschner wire fixation. Methods: We analyze clinical and radiographic data from n = 37 Gartland type III supracondylar fracture children, which was retrospectively collected at Islami Bank Medical College Hospital and multicentered hospital, Rajshahi, Bangladesh, over the 2-year period of January 2019 to December 2020. The average follow-up duration was over 1 year in all cases. Flynn criteria, pain, neurovascular examination and complications were included in the clinical assessment (infection or iatrogenic nerve injuries). In the final radiograph, the humeroulnar angle was measured. Results: The average duration of follow-up was 22 months. The children's average age was 7.4 years. According to Flynn's criteria, functional outcomes in 100% were acceptable and aesthetic results in 89.18% of patients were satisfactory. In 4 (10.8 percent) patients, the results were classified as poor owing to loss of angle. The average angle on the reverse side was 9.40, whereas it was 11.20. The average visual analogue scale (VAS) score was 0 at the last follow-up. Complications associated with the damage were the missing pulse of 3 (8.1%) and 1 (2.7%) primary median nerve paralysis. Complications related to treatment include 3 (8.1%) iatrogenic ulnar nerve paralysis. Conclusion: Closed and percutaneous manipulation Kirschner wire attachment Garland type III supracondylar fracture is a successful technique that is minimally invasive. The wire fixation of Kirschner offered a biomechanically stable fixation, but with an increased risk of ulnar nerve damage.