Aim:To determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the Indian rural population. Study Design: The study included 50 women with one successful pregnancy and no history of miscarriages were selected as a control and total of 50 similar age group of pregnant women with recurrent pregnancy loss in gestational age up to ≤ 12 weeks verified by pregnancy test or ultrasonography. Method: Levels of thyroid hormones T3, T4 and TSH were estimated in pregnant and non pregnant women with recurrent pregnancy loss and controls. Result: The hypothroidism was found to be more significant cause of recurrent pregnancy loss in women as comparative to the euthyroid women. Conclusions: The study demonstrates that hypothyroidism has a statistically significant relationship with recurrent pregnancy loss in the first trimester and suggests that diagnosis of hypothyroidism could help couples with recurrent pregnancy loss to have a successful outcome in subsequent pregnancies.