Purpose of the study is to compare the pupil cycle time(PCT) of patients with type-II diabetes and healthy control subjects.To analyse the effect of different variables like age, sex, blood sugar,diabetes duration on PCT.Methods-The study was conducted on known type-II diabetes patients attending retina clinic and non diabetic patients attending Eye OPD of Regional institute of medical sciences,Imphal for a period of 2 years. 100 individuals were taken,out of these 50 were diabetics and 50 non diabetics.PCT was measured by focussing a narrow horizontally aligned beam of fixed dimensions at the inferior part of pupil to initiate rhythmic cycles of contraction and relaxation,and the cycle time was measured in milliseconds with a hand held stop watch.Mean PCT of diabetics was compared with non diabetics and its correlation with different variables such as age, diabetes duration,sex,blood sugar was done .Results-Mean PCT of diabetic patients was prolonged as compared to non diabetics and also there was prolongation of PCT with increasing age and diabetes duration.Conclusion-Type II diabetes is associated with prolonged PCT,and it gets more prolonged with the duration of diabetes.PCT can be used as a fast and reliable clinic test to assess the amount of autonomic neuropathy affecting pupil of a diabetic patient.

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