Abstract:Methicillin Resistant Staphylococcus aureus (MRSA) is an emerging multidrug resistant bug worldwide. Knowing prevalence of MRSA is important to know for choosing empiric therapy and to screen colonized patients or staff. As Staphylococcus aureus is most common among pus samples, we have selected to do this study in this region. All clinical pus samples after receiving to Microbiology department, immediately inoculated in basal media such as Nutrient agar, Macconkey agar, Blood agar, Brain Heart Infusion Broth and selective media including mannitol salt agar DNAse agar. All Media plates after inoculation were incubated for 24 hours at 37 0 C. Out of 136, 59 (43.3%) were Staphylococcus aureus and MRSA was 17 (28.8%). In the present study, 20.3% were staphylococcal isolates sensitive to penicillin, 45.7% were sensitive to erythromycin, 42.3% were sensitive to clindamycin, 71.1% were sensitive to cefoxitin & cotrimoxazole, 30.5% were sensitive to ciprofloxacin, 88.1% were sensitive to gentamicin, 96.6% were sensitive to linezolid and 100% isolates were sensitive to tigecycline, teicoplanin and vancomycin. Guidelines for the prevention and control of MRSA should be followed in hospital care settings. Screening of MRSA should make a definite policy on all seriously ill patients after admission.