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The goal of this study is a comparative analysis of the possibilities of physical education for children with health problems and the current status in boys and girls. Understanding the concept of impaired health is a precondition for the realization of the training process and possible integration in the process of physical education, according to the structure of health disadvantages. Quality of life assessment is performed on three levels. The first level are items that are given in the form of a statement. On the second level, item-like particles are observed in the sub-segments (scales that cover different dimensions of health and quality of life). The raw scores of each scale are transformed into standardized ones with a possible value of 1-4, which facilitates the interpretation of the results. The third level represents total physical and psycho-social health. Up to this level, there are certain mathematical procedures, based on the individual scale scores. Comparative analyses in regard of the cultural and gender specificities are provided, based on MANOVA and DISCRA analyses, within the introductory part, and 11 scales of the Questionnaire. Analysis of the data point out major differences in the possibility of physical activity application in children with medical conditions, with a special overview of boys and girls from diverse cultural and social backgrounds, in Serbia and the Northern Aegean region of Greece.