There is growing evidence that many large coastal boulder deposits found on the exposed rocky ocean shores were deposited by extreme storm waves rather than by catastrophic tsunamis, as previously thought. In addition, before the first discovery in the northern Adriatic a few years ago, such deposits were not expected in relatively shallow semi-enclosed inland basins. Here we report on a large coastal coarse-clast deposit on the central Adriatic island of Mana, which also contains numerous large storm boulders that weigh up to several tons. Large solitary boulders are also located outside of the deposit, closer to the partly submerged sea cliff and the wave impact. The erosion of the cliff top and displacement of the carbonate bedrock fragments began when the extreme waves inundated the lowermost part of the cliff edge, probably during the late Holocene sea-level rise. The UAS photogrammetry-based fragmentation analysis of the storm deposit and the calculated fractal dimension value indicate that the material was fragmented by multiple high-energy events. A comparison of the available photographs indicates that displacements of the most exposed solitary boulders probably occurred during Vaia, the last extreme storm that hit the Adriatic on the 29th of October 2018. However, the modeled maximum wave height south of Mana during the peak of the storm would be insufficient to move these boulders. Yet local geomorphology probably further influenced the increase in wave height that, in combination with specific geological features, caused displacements of the boulders. There is a shorter fetch affecting Mana Island with respect to the northern Adriatic boulder field in southern Istria. Thus, such an active local erosion of the generally stable eastern Adriatic karstic coast depends on the extreme storms that have a weaker impact in the central than in the northern Adriatic.