Hyperprolactinemia and Hypothyroidism adversely affects the fertility potential. The aim of our study was to assess the correlation between the Prolactin and Thyroid hormone levels amongst infertile females after excluding tubal and male factor. This hospital based descriptive study was conducted on 50 patients attending infertility clinic in Zenana Hospital, Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur from Jan 2015 to Jan 2016. Hyperprolactinemia was observed in 64% of the infertile cases in our study. In our study 27 female had hypothyroidism, out of which 74.07% had subclinical hypothyroidism and 25.93% had overt hypothyroidism.18%of patients had both Hypothyroidism & Hyperprolactinemia. 33.3% of hypothyroid females had hyperprolactinemia. 28.3% of hyperprolactinemic patients had hypothyroidism. Hence, measurement of both S.TSH and S. Prolactin levels should be done in infertility work up and treatment should be initiated accordingly to fulfill a woman's dream of motherhood.