Introduction: Chronic lymphocytic leukemia is a heterogeneous group of clonal neoplastic pathologies characterized by the proliferation of mature B or T lymphoid cells. It is a neoplastic disease characterized by a monoclonal proliferation of slow-division, immunologically incompetent B cells that mature in the bone marrow, lymph nodes and peripheral blood. Aim of the work: Aim of this study is to show the difference of demographic data in patients with chronic lymphocytic leukemia and its correlation with each other and with hematological parameters. Subjects and methods: After approval of the university ethical, this study was conducted in Minia University hospital and Upper Egypt oncology center during the period from April 2019 to May 2020. It was conducted on 30 newly diagnosed CLL patients and 30 apparently healthy individuals as control. All the study subjects were submitted to history taking considering age, fever, bleeding tendency, easy fatigability and history of hemolytic attacks and to clinical examination including pallor, purpura, hepatomegaly, splenomegaly and lymph nodes enlargement. Also all subjects submitted to routine laboratory investigations that include: CBC, ESR, renal function test, liver function test and LDH. Results: High percentage of smudge cells in peripheral blood films are associated with early stages or low to moderate CLL prognostic index in CLL patients.

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