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predicted higher EFS in patients with age >60, male sex, IPI 3-5 and stage II-IV (Figure 1D). Conclusion:New treatment modalities like CARTs, resulted in renewed interest in iPET adaptive frontline trial design strategies.Our results support the prognostic impact of iPET/CT in a prospective clinical trial setting and helps design and interpretation of ongoing and future clinical trials evaluating iPET/CT adaptive frontline trials.

Introduction: Diffuse Large B Cell Lymphoma (DLBCL), the most common non-Hodgkin lymphoma, despite having a standard of care treatment (R-CHOP), has heterogeneous clinical and molecular fea-

Increased LDH was observed in 33% of patients, β-2microglobulin in 23%, and erythrocyte sedimentation in 23%.Toxic antecedents: tobacco 30% and dental prostheses in 15%.The initial symptoms were mobility and pain of the teeth, a rapidly growing painful tumor in the jugal mucosa, and torpid oral ulcers.HIV positive in 16 patients, 13 with PBL and 7 with DLBCL.Treatment: it was carried out according to the histology, the patient's PS, viral status and date of diagnosis.The following regimes were used: CHOP, R-CHOP, CVP; R-CVP, CAVPE, CNOP; DA-EPOCH. In 15 patients there are no data on the treatment carried out. 6 cases received local radiotherapy. CNS prophylaxis with systemic methotrexate or intrathecal drugs was performed according to the schedule chosen and the patient's risk factors.Responses: complete remission (CR) in 37%, partial remission (PR) in 16% of those who underwent treatment. There's no data in 22 patients due to loss of follow-up.Follow-up time ranged from 1 year to 21 years. Conclusions:In this series of patients, we observed most aggressive histology, with fast growing locoregional tumors. Dental alterations led to consultations with stomatologists, who took diagnostic biopsies. There was a predominance of males, of B lineage, with middle ages predominate. The IPI and the stage were not useful tools for the evaluation of this pathology.The association with HIV was observed in 28% of the cases, the majority were PBL (68%), with increased DLBCL histology. Favorable responses were observed, with prolonged survival in cases with less aggressive histology.