The aim of this study was to analyse the association of poor self-perceived health with demographic, socioeconomic and lifestyle factors using data from the European Health Interview Survey. When applying the multiple logistic regression model, two demographic (male sex, older age), all four socioeconomic (low education level, unemployed and retired, living in households with lowest income, poor social support) and only one lifestyle factor (no alcohol consumption) were revealed as associated with poor self-perceived health. The association of socioeconomic factors with self-perceived health among the adult population in Croatia is direct and not mediated exclusively through lifestyle factors.