Drug-drug interactions is a frequently encountered issue in clinical practice, reduce effectiveness of treatment and lead to dangerous complications for the patients, possibly even death. The purpose of this study is to analyze contraindicated drug interactions when prescribing in some hospitals in Quang Ninh Province. Subjects and methods: List of concentrated contractor drugs applied Quang Ninh province and within the scope of payment of Health Insurance Fund in 2018. The result: the group of researchers developed the list of 112 pairs of the cotraindicated drug-drug interactions to serve as a reference to determine the appearing frequency of contraindicated drug-drug interactions over 519500 medical records and 1254099 prescriptions at 3 hospitals in Quang Ninh province. Of which, 26 contraindicated drug-drug interactions (0.006%) was found over 297 medical records and 789 prescriptions. 5 pairs with the most appearing frequency are: Amiodarone-Amitriptyline, Amiodarone-Moxifloxacin, Amiodarone-Colchicine, Levodopa -Sulpiride, Amiodarone-Haloperidol. Medical reccords with contraindicated drug-drug interactions were found in 13 different departments or interdisciplinary deparments from all 3 hospitals, of which the highest rates were found in Intensive Care Unit and Emergency Departments (24.2%), Endocrinology Departments (16.2%) and Cardiology Pediatric Departments (10.4%). The average age of patients with contraindicated drug-drug interactions in all 3 hospitals was greater than or equal to 67, most are inpatients. Conclusion: Based on retrospective data on drug prescribing at 3 hospitals in Quang Ninh Province, the study analyzed 26 pairs of common contraindicated drug interactions in clinical practice.
Keywords
Contraindicated drug-drug interactions, hospitals in Quang Ninh Province, medication review tools.
References
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