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Background and Aims:Patients on ventilatory support in intensive care unit (ICU) require sedation and analgesia to facilitate mechanical ventilation and endotracheal tube tolerance. The selection of the agent should be such that it does not interfere with the early extubation of the patients. We compared the efficacy of dexmedetomidine with midazolam to facilitate extubation of patients from mechanical ventilation in terms of the sedative properties, cardiovascular responses, ventilation, and extubation characteristics and safety profile.Materials and Methods:A total of 40 adult, mechanically ventilated patients of either sex, aged 18-60 years, meeting the standard criteria for weaning, randomized into 2 groups of 20 patients each, received intravenous infusion of dexmedetomidine (0.2-0.7 mcg/kg/h) or midazolam (0.04-0.2 mg/kg/h) as needed for Ramsay sedation scale 2-4. Extubation following standard extubation protocol was done. Time for extubation and vital parameters were regularly recorded.Results:The time to extubation in the dexmedetomidine group was significantly lower than in the midazolam group. Heart rate and blood pressure was significantly lower in dexmedetomidine group than the midazolam group at most of the times.Conclusions:Dexmedetomidine has clinically relevant benefits compared with midazolam in facilitating extubation due to its shorter time to extubation, more hemodynamic stability, easy arousability, and lack of respiratory depression.

A method is described for the determination of dipyrone and paracetamol in pharmaceutical preparations in which aliquots containing 1-15 mg of the sample are allowed to react with a known excess of potassium hexacyanoferrate(ll1) in 10 ml of 8 M sulphuric acid and 5 ml of 3% zinc sulphate solution at 35 "C in a thermostatically controlled water-bath for 15 rnin (paracetamol) or 25 min (dipyrone). The excess of potassium hexacyanoferrate(ll1) is then determined iodimetrically. The analysis of a mixture containing dipyrone and paracetamol in pharmaceutical preparations is carried out after their separation, which is based on the difference in their solubilities. On treatment with distilled water, dipyrone goes into solution while paracetamol remains insoluble and is subsequently dissolved in hydrochloric acid by heating on a boiling water-bath for 30 min. Results are within a &1.0% error.

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