A significant number of studies have assessed the impact of medical tourism from economic, technological and social perspectives. Few studies, however, have explored the development of the medical tourism sector from a sustainability perspective. This research brings a sustainability lens to medical tourism by extending Hart and Milstein’s framework (2003) for creating sustainable business value to advance the development of sustainable medical tourism facilities. To inform the analysis, the study conducted nine semi-structured interviews with members of the Jordan Medical Tourism Network (JMTN). Interview results confirmed the primary factors that motivate medical tourists, and characteristics of a sustainable medical tourism facility. The research provides insights on how sustainability is a driver of medical tourists’ decisions and a core aspect to be managed. The study also provides direction to advance sustainable medical tourism facilities in Jordan with replicability in other jurisdictions. The research proposes a path for medical tourism facilities to play further roles in their contribution to sustainable development by introducing a framework that aims to integrate four business strategies for establishing sustainable value through the integration of stakeholders’ interests and environmental practices.