Pandemic situations may contribute to the psychological impact on the community. This study was designed to enlighten nursing students at the college level on Cognitive Behavior Therapy (CBT). Students need to practice this therapy to overcome the anxiety, stress, and other psychological shock of the patient admitted to the hospital with the diagnosis of COVID-19. A one-group pre-test and post-test design were selected.In this study 35 nursing students undergoing 4th year of baccalaureate nursing program during an internship period at the College of Applied Medical Sciences, King Khalid University (KKU), Saudi Arabia were chosen as convenience sampling. This study was carried out during the academic year 2020-2021. Pre-test data was assessed using 20 questions about knowledge, and 10 questions associated with an attitude of resolving CBT. Teaching the CBT was carried out after the pre-test, using same question post-test data was collected after a one-week period. The responses got were exposed to statistical analysis using SPSS. The results showed significant differences between pre-test and post-test use on knowledge and attitude, also significant differences were identified in the attitude that “more effective treatment for psychological problem patient”. Based on the study data, the results illustrated that nursing students require practice with CBT. If students have knowledge of this therapy and an attitude toward implementing this therapy, they will look at changes. If the patient is admitted to the hospital, healthcare professionals give more importance to physical health, and psychological well-being, these kinds of therapy help the patient overcome the anxiety and stress during hospitalization Key words: Interventional education, Cognitive Behavior Therapy (CBT), Nursing practice