Objective:  To  illustrate congenital cystic lesions of the extra hepatic biliary tract on the idea of information of embryologic development through the magnetic resonance cholangiopancreatography (MRCP). Methods: Patients that were suspected to  have  been  suffering  from  biliary  disease  were  referred  to the MRI units, there the patients were narrowed done to confirm with the inclusion and exclusion cri-      teria, thereafter written and informed consent was obtained from them  and  the  procedure  was  ex-  plained to them in detail. MRCP was performed on a 1.5 Tesla  in MR unit, using phased-array coil for signal detection. Heavily T2 weighted images were  obtained  with  SSF-SE  technique.  The  axial  sec- tions were used for pancreatic and bile ducts whereas the coronal sections were used for the pancreatobiliary tract, axial and coronal source images and reformatted  images  were  evaluated  to-  gether for the possibility of any anomaly in extra hepatic biliary tract. This was an observational, cross sectional, prospective study with a  sample  size  of  377  patients.  Statistical  analysis  was  done  by  SPSS version 16. Results: Choledochal cyst was found in 11  of the 377 patients with a gender separate frequency of 6  out of 196 females and 5 out of 181 males, with a total frequency of 2.9% and a p-value at <0.001 which was significant. Conclusion: By identifying the inherent anomalies that  present  themselves  during  the  visualization  of the biliary tract through MRCP and MRI, while coupled with  information  regarding  the  clinical  signifi- cance of every entity, is vital for establishing an accurate diagnosis and in guiding acceptable clinical intervention and management.

Diffuse Large B-Cell Lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma (NHL). Elevated expression of c-MYC in DLBCL is associated with poor prognosis of the disease. In different cancers, c-MYC has been found regulated by different ubiquitin-specific proteases (USPs), but to date, the role of USPs in c-MYC regulation has not been investigated in DLBCL. In this study, in situ co expression of c-MYC and three candidates USPs, USP28, USP36 and USP37, have been investigated in both the ABC and GCB subtypes of DLBCL. This shows that USP37 expression is positively correlated with the c-MYC expression in the ABC subtype of DLBCL. Structurally, both c-MYC and USP37 has shown large proportion of intrinsically disordered regions, minimizing their chances for full structure crystallization. Peptide array and docking simulations has shown that N-terminal region of c-MYC interacts directly with residues within and in proximity of catalytically active C19 domain of the USP37. Given the structural properties of the interaction sites in the c-MYC-USP37 complex, a peptidyl inhibitor has been designed. Molecular docking has shown that the peptide fits well in the targeted site of c-MYC, masking most of its residues involved in the binding with USP37. The findings could further be exploited to develop therapeutic interventions against the ABC subtype of DLBCL.

A single case of a solitary juvenile polyp of the small bowel is presented in a 10 month old infant which produced a jejuno-jejunal intussusception. A review of the literature failed to show a similar case. The pathology of the polyp is discussed.