Dermatoscopy facilitates prediction of the corresponding histopathological findings in pigmented BCC, based on specific dermatoscopic features.
Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada vitiligo ile insülin direnci ve metabolik sendrom (MetS) arasındaki ilişkinin araştırılması amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Prospektif, gözlemsel vaka-kontrol çalışması olarak planlanmış olan araştırmamıza vitiligo tanısı ile takip edilmekte olan 40 hasta ve hastalar ile yaş ve cinsiyet bakımından benzer 23 sağlıklı kontrol dahil edildi. Açlık kan örneklerinden; glukoz, insülin, C-peptit düzeyleri ve lipid profilleri çalışıldı. İnsülin direnci, HOMA-IR (Homeostatis Model Assessment Insulin Resistance) metodu ile hesaplandı. Ayrıca katılımcıların vücut kitle indeksleri hesaplandı, bel çevresi ve sistolik -diastolik kan basıncı ölçümleri kaydedildi. MetS tanısı, güncellenmiş Ulusal Kolesterol Eğitim Programı Erişkin Tedavi Paneli III kriterlerine göre konuldu. B Bu ul lg gu ul la ar r: : Serum insülin düzeyi vitiligo hastalarında kontrol grubundan yüksek iken (p=0,09), insülin direnci varlığı açısından vitiligo (%27,5) ve kontrol (%21,7) grupları arasında fark yoktu (p=0,61). Vitiligo ile MetS ilişkisi incelendiğinde vitiligo hastalarının %30'unda MetS görülürken, kontrollerin %26,1'inde MetS saptandı (p=0,74). MetS ile cinsiyet, vitiligo tipi, hastalık süresi ve yaygınlığı arasında anlamlı bir ilişki saptanmadı. Trigliserit düzeyi yüksekliği vitiligo hastalarının %35'inde ve kontrol grubunun %13'ünde mevcuttu (p= 0,059). MetS'un diğer parametreleri açısından vitiligo ve kontrol grubu arasında fark saptanmadı. S So on nu uç ç: : Çalışmamızda vitiligo hastalarında dikkate değer bir şekilde serum insülin düzeyi daha yüksek ve trigliserit düzeyi yüksekliği daha sık tespit edilmiş olsa da kontrol grubu ile aradaki farklar anlamlı değildir. Ayrıca, vitiligo hastalarında insülin direnci veya MetS prevalansında anlamlı bir artış saptanmamıştır.A An na ah ht ta ar r K Ke el li im me el le er r: : Vitiligo; insülin direnci; metabolik sendrom; oksidatif stres A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to investigate the relationship of vitiligo with insulin resistance and metabolic syndrome (MetS). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty vitiligo patients and 23 age-and gender-matched healthy controls were included in this prospective, observational case-control study. Fasting blood glucose, insulin, C-peptide levels and lipid profiles were quantified. Insulin resistance was calculated with the homeostatis model assessment insulin resistance (HOMA-IR) method. Body mass index, waist circumference and systolic-diastolic blood pressure measurements of the participants were recorded. MetS diagnosis was established according to the revised criteria of National Cholesterol Education Program Adult Treatment Panel III. R Re es su ul lt ts s: : Serum insulin level was higher in vitiligo patients than the control group (p=0.09); however there was no difference in terms of insulin resistance between vitiligo (27.5%) and control (21.7%) groups (p=0.61). MetS was detected in 30% of the vitiligo patie...
Background and Design:The aim of our study was to determine the frequency of fibromyalgia syndrome in chronic urticaria patients. Materials and Methods: The study was carried out with the participation of 100 chronic urticaria patients and 61 control group patients. Chronic urticaria patients were investigated for the etiology of urticaria and the autologous serum skin test was performed in those patients. Both the chronic urticaria patients and the controls were evaluated for fibromyalgia syndrome, and the patients fulfilling the diagnostic criteria were diagnosed to have fibromyalgia syndrome. Results: The frequency of fibromyalgia syndrome was significantly higher in chronic urticaria patients (23%), than in the control group (1.6%). All the patients, who were diagnosed with fibromyalgia syndrome, were female and the rate of female gender was significantly higher than in the group without fibromyalgia syndrome. Thyroid autoimmunity was positive in 26% of chronic urticaria patients. No significant difference was detected in the frequency of thyroid autoimmunity and autologous serum skin test positivity between the patients with and without fibromyalgia syndrome. Conclusion:The prevalence of fibromyalgia syndrome in chronic urticaria patients is higher than in the general population. Therefore, we suggest evaluation of chronic urticaria patients in terms of fibromyalgia syndrome which is a disease that decreases the quality of life considerably. Furthermore, in order to treat these two diseases effectively, future studies are necessary to determine the common points in the pathogenesis. (Turkderm 2014; 48: 215-8)
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