Relevance. The importance of breeding in increasing the productivity of agricultural animals can be perfectly demonstrated on the mulberry silkworm. For 5 thousand years, continuous selection was carried out, the main feature for which was silkiness. However, the more productive the object becomes, the more difficult and complicated traditional breeding turns out to be.Methods. New methods of breeding can be developed as a result of the use of artificial methods of reproduction. The implementation of all methods of artificial reproduction known to science (ameiotic and meiotic parthenogenesis, gynogenesis, androgenesis, polyploidy) with various cytogenetic mechanisms and methods of sex regulation to the silkworm has opened up new experimental possibilities. This makes it possible to control the inheritance of traits in a population within a wide range, which is especially effective when using artificial breeding methods in combination, for example, when breedinghybridizing parthenogenetic clones and sex-determined silkworm. Mеthods of breeding, preservation and use of genetically modified silkworm breeds have been worked out and repeatedly tested.Results. The industrial hybrids created in our research by breeding parthenogenetic clones and sex-labeled breeds at the egg stage are characterized by high heterosis in caterpillar viability (95.0–96.0%), ease of preparation of hybrid grene, economic benefits due to the abolition of breeding work, cocoon sorting, as well as expensive, lengthy and very inaccurate cocoon division by gender.

Natural silk was and remains the most elite and luxurious material. Silk is made from cocoons of the silkworm (Bombyx mori L.). The silkworm is part of the Holometabola group (insects with complete transformation). This means that the silkworm goes through several stages of development: egg, larva with four molts, pupa, butterfly. Each stage, depending on the breed and conditions of maintenance, is characterized by a certain duration and the so-called amity of development. In Uzbekistan, it is customary to carry out one feeding per year, timed to the beginning of the mulberry vegetation, therefore, tens of billions of caterpillars are simultaneously subjected to reproduction for 28–30 days. Changing the duration of any of the stages of development of the silkworm leads to destabilization of the feeding process and, as a result, to large material losses. Selection by motor activity, which implies the selection of the most active, and therefore the most viable individuals, leads to an acceleration of the metabоlism of the silkworm, synchronizes the development of a huge number of organisms at all stages of development, allows to coordinate with accuracy up to 1 day the work of all departments of the silk industry, accurately calculate time, human resources, the use of technical means and monetary costs for each stage and the entire cycle of reproduction of the silkworm.