Involvement of the vulva and vagina in Crohn's disease (CD) is rare and underdiagnosed because many other more likely inflammatory processes in this area are considered. Late diagnosis and ineffectiveness of treatment lead to the development of complications, a decrease in the quality of life of women. A clinical case of a lesion of the vulvovaginal zone in a young patient, regarded as extraintestinal (metastatic) CD, is presented. The presented clinical case shows the effectiveness of treatment with ustekinumab for poorly controlled CD and extraintestinal manifestations of this disease, in particular, the effectiveness of treatment of chronic vulvovaginitis has been demonstrated.