Abstract. Patient-specific blood flow modelling helps to predict surgical operation results, gives new noninvasive diagnostic methods, allows to investigate physiology of vascular pathologies. We develop numerical models for such medical applications. 1D blood flow model describes hemodynamics in the whole vascular network. 3D model of fluid flow can be embedded in the 1D model to zoom the domain of interest or to take into account pathologies or implants. We personalize the model, using patient-specific vascular structure and parameters. For some vascular regions extraction of patient-specific geometry can be automatic within developed technology. We verified the 1D model of blood flow. Two examples of real medical applications are presented. The method for FFR estimation is proposed. Also we used the 1D model for prediction of surgical occlusion treatment.
A MANCOVA with sex and age as covariates revealed the effect of the 'DRD2 x HTR2C x diagnosis' interaction on the BAS scores (p=0.033). The effect was significant for the Fun-Seeking and Drive scales. Among patients, the carriers of the DRD2 TT/CT x HTR2C GG/G genotype showed the highest scores on the both scales, and those with the minor alleles in the two loci had the lowest ones. Differences between these groups were nominally significant for both the Fun-Seeking and Drive, but did not survive the correction for multiple comparisons. Among controls, subjects without minor alleles demonstrated the highest scores on these two scales. They differed significantly from the carriers of the DRD2 TT/CT+HTR2C GG/G genotype on the Fun-Seeking (p=0.008). No effects of DRD2 and HTR2C on TEPS scores were found. In general, the results of the study can be interpreted in favor of the hypothesis about the role of the HTR2C and DRD2 genes interaction in the variability of the activational aspects of approach motivation in schizophrenia and healthy subjects. However, the lack of differences survived correction for multiple comparisons makes it difficult to interpret the revealed effects.
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