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The aim of the study was to develop and validate a software package (SP) for computer simulation of the procedure for examining patients with lung cancer by SPECT/CT and assessing the accuracy of reconstruction of tumor lesions.Material and Methods. Lung scintigraphy for a patient with peripheral squamous cell carcinoma of the upper lobe of the right lung was performed using a two-detector gamma camera GE Discovery NM/CT 670 DR (USA) with high-resolution collimators for an energy of 140 KeV and a radiopharmaceutical (RP) 99mTc-Technetril (MIBI, Diamed, Moscow). The data obtained were subjected to computer processing using a specialized Xeleris 4.0 system from GE (USA). The SP included a program for generating a voxel phantom (“virtual patient”), a program for modeling the “raw” data acquisition (“virtual tomograph”) and an image reconstruction based on the OSEM algorithm (Ordered Subset Expectation Maximization). In order to validate the created SP, computer simulation of the above clinical case was performed. The semi-quantitative comparative image analysis was based on a tumor/background score.Results. There was a good correlation between clinical “raw” data recorded from a real patient and projection data calculated by the Monte Carlo method from a “virtual patient”. The results of the comparative analysis showed that the tumor/background assessment was underestimated in the reconstructed images.Conclusion. The problem of the accuracy of the tumor lesions reconstruction by using standard OSEM reconstruction algorithms has not been studied. This issue is important in the management of patients with tumor lesions of the lungs and requires study and systematization. The SP will be used in further studies to analyze errors and artifacts in images of tumor lesions, as well as to develop approaches to overcome them.

Сквозной номер выпуска-109 Научный журнал УЧРЕДИТЕЛЬ И ИЗДАТЕЛЬ: федеральное государственное бюджетное образовательное учреждение высшего образования «Национальный исследовательский Мордовский государственный университет им. Н. П. Огарёва» 430005, Россия, Республика Мордовия, г. Саранск, ул. Большевистская, 68

Introduction. Promotion of volunteerism plays an important role in the formation of civil society in Russia. The animal welfare movement is one of the areas of such socially significant activities. Studies in this field are of relevance and practical significance, since the development of the animal welfare movement is a kind of social marker of the moral state of society. The study is aimed at identifying the organizational forms of the animal welfare movement in Russia as well as the motivation for people to participate in this activity, and at drawing up a sociological portrait of the Russian animal welfare activist. Materials and Methods. The article presents the results of two sociological studies: a survey of animal welfare activists (2017) done using the method of informal guided (semi-structured) interviews and an online survey of members of animal welfare groups on social networks (2019) conducted using ‘snowball sampling’ technique. Results. A portrait of a typical representative of the animal welfare movement in Russia has been done. The main achievements and problems of the animal welfare movement in Russia have been identified. The social composition of the animal welfare movement has been revealed as well as the activists’ motivation for participation in volunteering. An assessment of the level of development of the animal welfare in Russia as a whole and in the home regions of the animal welfare activists has been presented. Discussion and Conclusion. The animal welfare movement is represented at the regional and federal levels, the degree of its development being a certain marker of the state of public morality and the level of maturity of civil society. However, the effectiveness of animal welfare activities is constrained by a number of factors: legal, organizational, financial, and informational ones. Overcoming these barriers depends on a sustainable dialogue between the authorities and civil society, especially at the regional level. The practical significance of the study lies in the possibility of using its results by the authorities and volunteer movements for the implementation of civil initiatives and their legislative support at the federal and regional levels.