The current study was carried out in the Animal Production Research Station, Sakha Kafr El-Sheikh Egypt belonging to Animal Production Research Institute (APRI Animal Production Research Institute (APRI), EGYPT. Two experiments were carried out to evaluate the effects of dietary amino acid supplementation (Methionine or lysine) in the diet of local chicken breed AL-SALAM on the performance and serum chemistry. The control group contained 0.2 g lysine / kg diet and 0.2 g methionine / kg diet. Lysine levels were 1.12, 1.37 and 1.6 g lysine / kg diet. Methionine levels were 0.60, 0.64 and 0.68 g methionine / kg diet. We found that when adding access amino acid lysine to the diet at level (1.6%) or adding access methionine at levels (0.64 % and 0.68 %) increased daily body weight gain significantly, compared with the control group. Lysozyme's activity was increased when adding access amino acid methionine (0.64 and 0.68%M) then levels (.12%L, 1.37%L, 1.60%L, and 0.60%M, respectively) than the control group. Relative economic efficiency was better when adding access levels (1.60%L or 0.64 and 0.68%M), than other groups. Finally, we suggest adding access lysine with levels 1.60 (%) or access methionine with levels 0.64 and 0.68 % to rations of local poultry breeds from 14 days to reach market weight to reveal the best economic profit gain and to promote the economic efficiency, with reasonable cost.