No abstract

From the perspective of private paying source, the projection is that adding saxagliptine with MF save costs when compared with the addition of rosiglitazone or pioglitazone in patients with DM2 that have not reached the HbA1c goal with metformin monotherapy. The BIM of including saxagliptine in the reimbursement lists of health plans indicated significant savings on the three-year horizon.

A147patient population. Based on a representative population-based patient-cohort, the objective of this study was to develop a decision model that could reflect realworld practice and predict the costs throughout treatment pathway. Methods: All patients newly diagnosed with FL in the UK's population-based Haematological Malignancy Research Network (www.hmrn.org) between 2004 and 2011 were followed until 2014 (n= 741). The mapped treatment pathways, alongside cost information derived from the National Tariff 2013/14, were incorporated into a discrete event simulation in order to reflect the heterogeneity of clinical characteristics, such as stage, and treatment options. Results: The annual cost of treating FL across the UK (population ~ 64 million) was estimated to be around £17 million. The predicted mean cost per patient from diagnosis to death was £10,202. Based on the initial treatment decision average costs were; £17,054 for those treated with chemotherapy (46%), £4,651 for those treated with radiotherapy (12%), and £2,185 for those managed by "watch-and-wait" (42%). The model's predicted costs per patient captured 95% of the actual costs calculated from empirical data, supporting the validity of the model. ConClusions: This is the first modelling study using 'real world' evidence to predict costs of entire FL treatment pathways. As several expensive new technologies/treatments for FL are on the horizon, future application of the model developed here could be used to assess their economic impacts and support healthcare decision makers, especially in the era of personalised medicine.

High-volume hospital was the strongest predictor for shorter LoS, whereas SRC certification was the strongest predictor of lower ICU need. Public health policies targeting an increase of efficiency and patient access to the procedure should take into account these results.

Cost per responder analysis of biologic drugs for the treatment of moderate to severe psoriasis under Brazilian public and private healthcare systems perspectives