Background: Multiple myeloma (MM) patients compose approximately 10% of patients with hematological malignancies. Polyneuropathy (PN) is one of the most important complications related to the disease and treatment. Aims: Multiple myeloma (MM) patients compose approximately 10% of patients with hematological malignancies. Polyneuropathy (PN) is one of the most important complications related to the disease and treatment. Methods: A total of 121 MM cases followed in the Hematology Clinic of Atatürk Training and Research Hospital between 2010-2018 were included in the study. Electromyography results were evaluated retrospectively and clinical and laboratory findings were compared. Five cases with diabetes mellitus were excluded from the study. Chi-square method was accepted as statistically significant p < 0.05. Results:The median age of the patients was 64.5 (min 39 max: 88), and Female / Male ratio was 51/65 (44% / 65%). Demographic data of 28 (24.3%) patients with PN and 87 (75.7%) patients without PN were presented in Table 1. Renal function tests were normal in 64 (55.7%) of 87 patients without polyneuropathy (p = 0.005). There were 28 (23%) cases with extramedullary plasmacytoma larger than 1.5 cm which were detected by MR imaging at the time of diagnosis. In cases with extramedullary plasmacytoma, the prevalence of polyneuropathy was higher at the initial diagnosis (p = 0.012).