Аim. To study the severity of chronic erosive gastritis associated with Helicobacter pylori and Epstein-Barr virus depending on the number of copies of Epstein-Barr virus in biopsies of gastric mucosa. Materials and methods. The severity of chronic erosive gastritis associated with Helicobacter pylori in the presence and absence of Epstein-Barr virus in the gastric mucosa was compared in 65 patients, divided into 4 groups depending on the detection of Epstein-Barr virus in the gastric mucosa. Result. the presence of Epstein-Barr virus in the gastric mucosa aggravates the course of chronic erosive gastritis associated with Helicobacter pylori.

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Aim. Based on the histological conclusion, to evaluate the frequency of detection of helicobacteriosis and herpesvirus infection in patients with morphological changes in the gastric mucosa.Materials and methods. Retrospectively, according to the logs of registration of endoscopic studies and registration of directions for histological studies for 2017–2021 of the endoscopic office of the polyclinic No. 2 in Smolensk city of Russia, the results of histological studies of biopsies of the gastric mucosa in 651 patients tested for H. pylori infection and herpesvirus infection were evaluated.Results. It is preferable to consider in the formation of inflammation the influence not of individual H. pylori bacteria, but the value of the entire mucosal microflora of the stomach and duodenum. The role of herpes viruses in the development of inflammatory and destructive pathology of the stomach and duodenum is noted. In patients infected with H. pylori and HVI in the SOH, there are structural changes in which destructive processes may have a deeper character, which will affect the timing of achieving remission.Conclusions. 1). In the description of the histological picture of the gastric mucosa, H. pylori was determined in 85.41 % of cases: with polyposis –97.05 %, oncopathology – 100 %, peptic ulcer – 94.50 %, chronic gastritis – 89.28 % of cases. 2). Herpes types 1, 2, 6, 8, EBV, cytomegalovirus from 220 biopsies were detected in 83.18 % of cases. EBV was most often present in the gastric mucosa from herpesvirus infection – 74.20 % of cases (with peptic ulcer in 78.00 %, with chronic gastritis in 84.71 %). 3). Simultaneously, herpesvirus infection and H. pylori were detected in 120 patients: with peptic ulcer – 68.00 %, with chronic gastritis – 75.29 % of cases.