Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs. To assess cell proliferation antibodies to β-catenin, CD34, Ki67, and to Dkk-1 were used. Results. PRP treatment was more effective than minoxidil therapy (p = 0.005). Complex therapy turned out to be more effective than minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). After applying PRP the absolute and relative values of the β-catenin and CD34 expression area increased; an increase in Ki67+ index was also significant. Conclusions: PRP can be considered as a treatment option for AGA. Combined PRP and minoxidil use seems promising for the treatment of AGA. PRP increase in the proliferative activity of HF cells and improves hair morphology in patients with AGA.
The aim of the study was morphological substantiation of clinical efficacy of platelet rich plasma (PRP) in the treatment of patients with androgenetic alopecia (AGA). Materials and Methods: The study included 25 men aged from 20 to 43 years. AGA degree II-IV on the Hamilton-Norwood scale was diagnosed in 23 (92%) patients and degree I in 2 patients. All patients received intradermal injections of PRP. The course of treatment consisted of 4 procedures with an interval of 4 weeks between each procedure. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric indicators of hair growth. The morphological analysis included an assessment of indicators in horizontal sections and was carried out at 4 levels: at the level of subcutaneous adipose tissue, sweat glands, sebaceous glands, and mouths of hair follicle (HF). Sections were stained with H&E. Histological examination was performed before and after treatment. Against the background of treatment with PRP, hair density increased by 12% (P=0.000), average hair diameter by 12% (P=0.002), and the share of vellus and telogen hair decreased by 17% (P=0.002) and 16% (P=0.028), respectively. At the same time, the amount of anagen hair in relation to telogen hair increased by 18% (P=0.016). Histologically, the increase in hair density was accompanied by a significant increase in the number of HF at the mouth level (∆+96%, P=0.004) and at the level of sweat glands (∆+54%, P=0.037), as well as a tendency for their number to increase at the level of the sebaceous glands. These increases were combined with a significant decrease in the proportion of telogen hair (∆-43%, P=0.023) and vellus hair (∆-29%, P=0.037). Conclusion: The positive clinical effect of PRP therapy is due to significant morphofunctional changes in hair follicles.
Morphological substantiation of the clinical efficacy of platelets rich plasma was carried out in the treatment of 22 men with androgenetic alopecia from the 1st to the 4th stage according to the Norwood-Hamilton scale were included. All patients received intradermal injections of platelets rich plasma 0,15 ml per injection. The course of treatment consisted of 4 procedures with an interval of 4 weeks. Clinical efficacy was assessed by the dynamics of morphometric indices of hair growth. Histological examination was carried out on horizontal sections, stained with hematoxylin and eosin, the morphology of the hair was counted at four levels. Evaluation of morphometric growth parameters conducted before treatment and 4 months after the onset of it. It was established that the therapy of platelet-rich plasma has a pronounced clinical efficacy, consisting in a significant (p=0,00025) increase in hair density by 11% and average hair diameter by 10% (p=0,00766), a 14% decrease in the share of hair follicles (p=0,00959). Histologically, the increase in hair density was significant at the level of the bulb of the hair follicles by 148% (p=0,0034) and at the level of the sweat glands by 65% (p=0,0326), and also by the tendency to increase their number at the level of the sebaceous glands. This was combined with a significant decrease in the proportion of telogen hair at 47% (p=0,0153). Thus, the positive clinical effect of plasma-rich plasma therapy in men suffering from androgenetic alopecia is based on reliable morphofunctional changes in the hair follicles.
The authors of [1] proposed a method for constructing a phenomenological equation for a dynamic system that is one of the constructive forms of analytic mathematical descriptions of complex (multifactor) objects (systems) that are difficult to formalize. However, the constructed equation was validated under the assumption that the connectivity and the degree of the polynomial equation are known (found), and the problem is thus reduced to simply finding coefficients.Below we develop a solution to the problem for the case of a priori unknown connectivity and degree for the desired phenomenological equation.Statement of the Problem. We will study some generally nonlinear dynamic (time varying) system, assuming that measurements (observations) are made only of the output signal X k, which is recorded at discrete times t = tk:X k = X(tk), k = 1, 2 ..... N. We neglect the measurement error and external noise, assuming that tt.e measurements of k k are exact. Analysis of the stability of our algorithm in the presence of measurement error and external noise is an independent problem whose solution is beyond the scope of the present article.We assume that the operation of the system can be described by some phenomenological equation, generally stochastic, i.e., )-.=f(~-~_,,L._ 2, ,~-k_.)+{.;fE F ,
The article describes the features of design and light distribution of automobile LED head lighting. The comparative lighting tests of LED headlamps and conventional ones were carried out.
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