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Phosphonium bis-zwitterions based on bis-2-cyanoacrylates are weak reversible inhibitors of choline esterases with a diverse anticholine esterase effect. This can find use in additional classification of choline esterases.

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Anticholine Esterase Activity of Phosphonium Bis-zwitterions Based on 2-Cyanoacrylates. -Phosphonium bis-betaines (III) based on 2-cyanoacrylates are synthesized and evaluated as inhibitors of choline esterase. The compounds (III) show a weak inhibition effect on choline esterases from various sources. -(ZHUKOVSKII, YU. G.; KUZNETSOVA, L. P.; SOCHILINA, E. E.; BYKOVSKAYA, E. YU.; KRYLOVA, T. O.; KOLOMNIKOVA, G. D.; GOLOLOBOV, YU. G.; Russ.