Land pollution due to the use of chemical fertilizers, and trying to use materials that do not have harmful effects on the environment, so this present study was conducted to evaluate the effect of biofertilization as arbuscular mycorrhiza fungi (MF) , potassium humate (KH) and rates of N, P and K fertilization on the growth , yield and economic indicators of soybean plants,in a private farm during the summer seasons 2021 and 2022. In randomized complete block design, the experimental was consisted of 3 replicates. The treatments were control treatment (100 % NPK of the recommended) , 75 % NPK , 75% NPK + MF, 75% NPK+ KH , 75 % NPK+ MF + KH , 50 % NPK , 50 % NPK+ MF, 50% NPK+ KH, 50 % NPK+ MF + KH . The obtained results indicated that, The addition of 75 % NPK+ MF + KH attained the highest values of plant growth , yield , nutrients uptake and net return compared to Control treatment100 % NPK. In this treatment increases of 13.93 , 17.57 , 36.71% were reached for seed N, P and K uptake, respectively. While seed yield and net return the increases were 9.44 , 64.96 % , respectively. Generally, the application of mycorrhiza fungi (MF) and potassium humate (KH) with 75 % NPK recommended dose attained the best results for all aforementioned characteristics in both seasons as well as saved 25 % of NPK requirement and maximize the net return for soybean plants by safe natural sources .