Four new azomethines have been synthesized. Quantum-chemical calculations of the atomic electron density distribution in the synthesized and known azomethines have been carried out. Their antioxidant activity has been studied in a model system with linolenic acid as the substrate. It is established that the electron density on the carbon atom of azomethine group is correlated with the antioxidant activity in the series of azomethines containing NO 2 groups in their structures. 474 0091-150X/07/4109-0474