Scvcrc clilcval ntutritional ncurological dairiagc in a VOLIng Nigcrian detaincc. i'rip Gcoigr .led in press. 3 B3akcr JP,)ctskv AS, WessonDEl , e ta!. Ntutritional iisscssment: a comrparison ot clinical uldgemcrnt anid ohtective measurement' A nI ng,7 1ed 19X2;306: 969-72. 4 W'aterlon J(.. (lassificatirn and dctliniltoin o pro(tc'in-cloric nmalnlutritioni. BJI4J 1972:iii:566-9. 5 Siith R. Lessons t'rorim Atiicric-a; rescarch in the prisuiis can bring peace. B3117

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Both tibolone and CEE plus MPA increased CRP levels and reduced levels of vitamin B12. Neither therapy had any significant effect on homocysteine levels. Further long-term studies into the effect of HRT on these markers, and the relationship to cardiovascular disease risk, are required.

In view of a similar and characteristic response of LDL subfractions to hypolipidaemic drugs that enhance the clearance of LDL via the LDL receptor, the present findings suggest that oestrogen promotes the preferential removal of LDL-I and II by activating LDL receptors. As this effect is normally associated with a reduction in the circulating level of LDL, it should not be regarded as an unfavourable response to oestrogen replacement therapy.