As women fertility is obviously decreasing at present, a number of people who, being at the reproductive age, suffer from various diseases is only growing and it is truly a vital issue. Chronic endometritis which is a problem in contemporary gynecology and reproductive performance studies may cause menstrual function disorders, anemia, and chronic pelvis pains syndrome. Our research goal was to assess risks of somatic pathology evolvement and life quality of women suffering from chronic endometritis. The focus group was made up of 42 patients at their fertile age who suffered from chronic endometritis (n=42); the reference group consisted of practically healthy females at the same age (n=33) who applied to a gynecologist in order to make a choice on a contraceptive. We detected that women with chronic endometritis had somatic pathologies much more frequently that women from the reference group; such pathologies included chronic gastritis, functional disorders in the bowels, gall-bladder diseases, urinary system diseases, and chronic rhinopharyngitis (relative risks varied from 1.25 to 4.62; p<0.05). High somatic pathology parameters indicate there is a decrease in immunologic protection and non-specific reactivity to pathologic changes in molecular mechanisms involving tissue and cellular homeostasis disorders. Patients form the focus group had lower life quality, weaker endurance and greater fatigue, lower emotional and social activity. When doctors of all specialities treat patients with chronic endometritis they are advised to apply healthrestoring treatment at any stage when a patient applies for medical assistance (and not only when she is getting ready for a pregnancy). We highlight the necessity to create individual sets of pharmaceuticals, physiotherapy and balneal techniques, and diet therapy for basic metabolic processes recovery, antioxidant processes recovery, immunologic protection and non-specific reactivity improvement. It is also necessary to treat not only gynecological pathology, but also a concomitant somatic one.

Inflammation is considered a typical response to tissue injury. At present, we see an increasing number of patients with chronic inflammation, where the damaging factor is unclear. Specifically, the pathogenetic factors of chronic endometritis (СЕ) need to be studied both in the gynecological and somatic aspects of the disease, including the functional state of other organs and systems.Aim: to analyse the microflora of the urinary tract and the intestines in patients with СЕ and various somatic conditions.Materials and methods. The intestinal and urinary tract microflora were assayed using microscopic, microbiological and molecular biological methods. To prevent false positive results and minimize sample contamination, we used our own modification.Results. The intestinal microbiota in patients with СЕ significantly differed from that in relatively healthy controls. We found a relationship between the abnormal colon microflora and the diseases of the upper and lower gastrointestinal tract, in particular, chronic cholecystitis, gastritis, and functional disorders of the intestine. These findings may become important for compbined therapy.Conclusion. The results indicate the need to individualize the pharmacol therapeutic treatment of patients with СЕ, especially those with impaired fertility. The treatment strategy should be based on minimizing the adverse drug effects, and considering the concomitant diseases.

The article discusses the features of obstetric and gynecological anamnesis in patients with endometrial polyps in the postmenopausal period, compares the ultrasound protocols and data of morphological examination of the surgical material (n = 100). The results showed that endometrial polyps are detected with the same frequency in patients in the early and late postmenopausal period. It is noteworthy that every five patient with an endometrial polyp in the reproductive age had menstrual dysfunction and a high frequency of using intrauterine contraceptive. In order to verify the pathology of the uterine cavity, ultrasound infusion sonography was not used in the studied group of patients. There was a high frequency of the absence of visualization of endometrial polyps on TV ultrasound, besides, they were frequently verified as endometrial hyperplasia; overdiagnosis took place in more than 7.5 cases; morphological examination confirmed hyperplasia only in 8% of 60 % of patients. It is important to note that in case of malignant endometrial processes, TV ultrasound did not reveal even a suspicion of this. All of the above allows us to say that there is a need for further study of the tactics of managing patients with endometrial pathology in the postmenopausal period.

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