PURPOSE: In the last 20 years, the demand for effective universal natural chemoprotectants and radiomodulators has increased. In this article, we provide evidence for the antioxidant and protective nature of herbs and their potential to be used as nutritional antioxidants, DNA modulating agents, metabolic radiation scavengers, immunomodulatory agents of SARS-COVID-19 infection, hepatoprotectors. The main action of natural antioxidants (Silybum marianum, Curcuma longa Linn, Haberlea rhodopensis Friv, Tinospora cordifolia (Willd.), Lemna minor Linn., Sambucus nigra Linn.) is carried out by capturing free radical structures, signaling redox modulation, compensating of oxidative disturbances, regulation of cell proliferation. Future development of effective herbal combinations with conventional chemotherapeutics, neutralizing systemic oxidative stress and predisposing to a reduced risk of developing cardiovascular, pulmonary and neurodegenerative diseases, cancer, etc., is necessary.