Haemostatic and lipid parameters were determined for groups of women treated for at least 3 years with different types of hormonal contraception (HO, and compared to data of matched control groups without contraception and with IUD. A group of women starting HC were examined before HC, and after I cycle, 3 cycles and 1 year of HC.Slight increases of factor VII and thrombotest were observed immediately with all HC. Cold activation of thrombotest was observed with much higher frequency and at higher levels in HC groups than in controls. Decrease of antithrombin III was most markedly observed with the immunological assay, and occurred progressively throughout the first year of treatment. Fibrinolytic activity was affected differently by progestagen which fnc eased euglobulin lysis time, and by combined HC which shortened it. Plasminogen activator values confirmed these results. Response to local anoxia was not significantly modified. Significant increases of total lipids and phospholipidsand a slight increase of chblesterol occurred progressively during the first year of HC.As these modifications are possibly involved in thrombotic accidents in predisposed or high-risk women, and are more likely to occur during the initial period of He, closer supervision remains advisable during this period.

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