curves. Cumulative TB rates were expressed as time after UK entry and time after GP registration and compared between immigrant subgroups stratified by WHO incidence in country of origin (150e499/100 000 or 500+/100 000) and age group at time of registration (<16, 16e35 or ¼36 years). The number needed to screen was calculated using an overall prevalence estimate of 25% IGRA positivity, with all cases occurring in this subgroup. Results 564 cases were recorded in 34 764 immigrants. The median (IQR) observation was 2198 (982e3329) days after UK entry and 956 (358e1888) days after GP registration. There was no difference in risk with time after UK entry or GP registration and the TB rate rose linearly over 10 years. In our cohort, the 5-year cumulative TB rate was significantly higher for immigrants from regions with incidence of 150e499 than those from 500+. The TB rate was also significantly higher in adults than children, and highest in adults aged 16e35 years (Abstract P55