Orale Kontrazeptiva stellen ein wichtiges bevölkerungspolitisches Korrektiv unserer Zeit dar. Ebenso alt wie di Präparate sind die Berichte über die durch sie hervorgerufenen Nebenwirkungen. In zahlreichen Studien wurde auf Störungen des 26,39), der Blutgerinnung (7), des Blutdrucks ( 22) und der Psyche (14, 18, 19, 29) hingewiesen. Wilbert und Mitarbeiter (47) teilten bereits im Jahre 1969 in dieser Wochenschrift mit, daß über 60 verschiedene klinisch-chemische Parameter unter hormonaler Kontrazeption verändert sein können. Demgegenüber weisen nur wenige Autoren auf eine Beeinflussung der Vitamine als Folge einer Einnahme von Ovulationshemmern hin (21). Vitamin A Im Jahre 1971 fanden Gal und Mitarbeiter (13), daß bei der Einnahme von Ovulationshemmern eine signifikante Erhöhung der Plasmakonzentration von Vitamin A nachweisbar ist.
In eight patients suffering from polycythaemia vera, the proliferation of erythroid colonies in methylcellulose with and without exogenous erythropoietin was studied. After three and five weeks, respectively, no colonies grew. Due to addition of erythropoietin more erythroid colonies proliferated which could be cultivated over nine weeks. The experiments suggest that the erythropoiesis in polycythaemia vera depends on erythropoietin.
In 20 patients, suffering from various diseases, the extent of haemolysis and the correlation between the rate of haemolysis and various mechanisms of erythrocyte damage in the course of open heart surgery was studied. We investigated haemotological parameters, electrolytes, lactate dehydrogenase before, and 1, 3, 5, and 7 days after operation. Besides free haemoglobin, haptoglobin and haemopexin were determined 5 and 15 minutes after starting perfusior with the heart-lung machine and after finishing. The best index of haemolysis was free haemoglobin in the serum. With increasing duration of perfusion the rate of haemolysis increased. Compensating mechanisms were postoperative increase of haptoglobin and haemopexin.
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