Results: As expected, eGFR fell from 85AE18ml/min at baseline to 59AE12ml/ min, 12 months post-donation (P<0.001). Clinic BP was 123AE15/79AE9mmHg at baseline and 126AE14/75AE9mmHg, 12 months post-donation (PZ0.09 and P<0.001 for systolic and diastolic BP, respectively). There was no change in aPWV from baseline, 12 months following donation (7.33AE1.53m/s versus 7.35AE1.1.58m/s, PZ0.8).Conclusion: These data demonstrate that it is feasible to recruit patients undergoing living-donor nephrectomy and to examine the effects on aortic stiffness up to 12 months following donation. Moreover, the results provide important data on which to base larger studies aimed at investigating longerterm effects of kidney donation on aortic stiffness and cardiovascular health.