BACKGROUND In April 2015, the government of Georgia (country) initiated the worldʼs first national hepatitis C elimination program. An analysis of blood donor infectious screening data was conducted to inform a strategic plan to advance blood transfusion safety in Georgia. STUDY DESIGN AND METHODS Descriptive analysis of blood donation records (2015‐2017) was performed to elucidate differences in demographics, donor type, remuneration status, and seroprevalence for infectious markers (hepatitis C virus antibody [anti‐HCV], human immunodeficiency virus [HIV], hepatitis B virus surface antigen [HBsAg], and Treponema pallidum). For regression analysis, final models included all variables associated with the outcome in bivariate analysis (chi‐square) with a p value of less than 0.05. RESULTS During 2015 to 2017, there were 251,428 donations in Georgia, representing 112,093 unique donors; 68.5% were from male donors, and 51.2% of donors were paid or replacement (friends or family of intended recipient). The overall seroprevalence significantly declined from 2015 to 2017 for anti‐HCV (2.3%‐1.4%), HBsAg (1.5%‐1.1%), and T. pallidum (1.1%‐0.7%) [p < 0.0001]; the decline was not significant for HIV (0.2%‐0.1%). Only 41.0% of anti‐HCV seropositive donors underwent additional testing to confirm viremia. Infectious marker seroprevalence varied by age, sex, and geography. In multivariable analysis, first‐time and paid donor status were associated with seropositivity for all four infectious markers. CONCLUSION A decline during the study period in infectious markers suggests improvement in blood safety in Georgia. Areas that need further improvement are donor recruitment, standardization of screening and diagnostic follow‐up, quality assurance, and posttransfusion surveillance.

In the conditions of mass vaccination of hepatitis B, all over the world, including in Georgia, in the vaccinated population, the numberof those individuals who could not develop Anti-HBs are growing every day. According to the literature, the main reason for the ineffective vaccination of hepatitis B is considered to be an increase in the prevalence of express mutants among the hepatitisB virus population, which is of a similar intensity throughout the world. In parallel with a detailed analysis of literature sources, the scientific article for the first time studied the seroprevalence of Anti-HBs in the population of Georgian vaccinatedchildren.