Gpr126/Adgrg6, an adhesion family G protein–coupled receptor (aGPCR), is required for the development of myelinating Schwann cells in the peripheral nervous system. Myelin supports and insulates vertebrate axons to permit rapid signal propagation throughout the nervous system. In mammals and zebrafish, mutations in Gpr126 arrest Schwann cells at early developmental stages. We exploited the optical and pharmacological tractability of larval zebrafish to uncover drugs that mediate myelination by activating Gpr126 or functioning in parallel. Using a fluorescent marker of mature myelinating glia (Tg[mbp:EGFP‐CAAX]), we screened hypomorphic gpr126 mutant larvae for restoration of myelin basic protein (mbp) expression along peripheral nerves following small molecule treatment. Our screens identified five compounds sufficient to promote mbp expression in gpr126 hypomorphs. Using an allelic series of gpr126 mutants, we parsed the ability of small molecules to restore mbp, suggesting differences in drug efficacy dependent on Schwann cell developmental state. Finally, we identify apomorphine hydrochloride as a direct small molecule activator of Gpr126 using combined in vivo/in vitro assays and show that aporphine class compounds promote Schwann cell development in vivo. Our results demonstrate the utility of in vivo screening for aGPCR modulators and identify small molecules that interact with the gpr126‐mediated myelination program.

A lethal case of trichlorethylene poisoning is reported. A 50-year-old woman had drunk some 100 ml of pure trichlorethylene. The trichloracetic acid found only in traces in her urine indicated that death apparently occurred very rapidly. Furthermore, substances contained in the hair tonic "K5-Tinktur" were found in remnants of the corps in safekeeping. Skin burns around the mouth, and also on the mucous membrane of the vestibule of the mouth, were striking. The special odor during the autopsy indicated poisoning by organic solvents. The fact trichlorethylene taken orally produces an intense X-ray attenuation is mentioned with regard to the diagnosis of poisoning by halogenized hydrocarbons and to therapeutic measures. The lethal result was due to the narcotic effect of trichlorethylene.

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