Excessive IWL is a well known complication in prematures placed under radiant warmers. A controlled study was therefore undertaken to determine if a plastic dome would be useful in minimizing IWL. Twenty-nine AGA healthy infants with gest. age of 30.95.4 wks (mean5.E.) birth wt. 1.42.03kg and postnatal age of 8.7+2.1 days were studied. IWL was determined from insensible wtr loss measured on a Potter Bed Balance scale. Water losses from urine and stool were prevented by attaching a plastic pouch to the perineum. IWL was measured under 2 conditions in the same infant: with heat shield (Grp A) and without heat shield ( G r p B). Each study period extended for 3 hrs after 30 min. of stabilization. The studies were done in an infra-red radiant warmer (Ohio) with servo-control set at skin temp. . 1975 at Downstate Medical Center. Two-hundred and fortysix mothers developed toxemia. The incidence of RDS (15%) in tht toxemia group was significantly (p<0.001) lower than that (30%) in the non-toxemia group. In infants whose gestational age was 34 wk or less, the incidence was 21% in the toxemia group and35: in the non-toxemia group (p<0.001). In infants whose gestational age was 35 wk or more, the incidence (6%) in the toxemia group was significantly (p<0.05) lower than that (15%) in the non-toxemia group. Toxemia was classified into 6 groups; mild preeclampsia (I) ,severe pre-eclampsia (2) ,anteparturn eclampsia (3), intrapartum eclampsia (4) ,hypertensive before pregnancy with toxemia (5) ,hypertensive before pregnancy without toxemia (6). The incidence of RDS was 21% in group 1.13% in 2,9% in 3, 0% in 4,10% in 5 and 15% in 6. It appears that the incidence of RDS was inversely related to the severity of maternal toxemia (group 1-4). The incidence of RDS was significantly (~(0.005) lower in infants of mothers who had hypertension before pregnancy with or without toxemia. Our study demonstrated the low incidence ofRD! in premature infants of toxemic mothers and inverse relationship between the development of RDS and the severity of maternal toxemia. From Jan.1975 to June, 1977, 113 infants of drug-addicted mothers (IOAM) were studied and compared to 5903 infants of non-addicts at Downstate Medical Center. There were no differences in the ethnic backqroud.materna1 aqe and parental education between the study and control groups. Of 113 pregnant addicts, 69 were taking multiple drugs. The incidences of maternal urinary tract infection,positive STS and fetal distress were significantly (~(0.005) higher compared with the con trol group. Mean birth weight and gestational age in the study group were 2807 q and 38.5 wk respectively. The high incidence of low birth weight (27%) was mainly due to prematurity (21%). THE EFFECT OF MOTHERS' DRUGMean birth weight (2435 g) of 8 infants of pure heroin addicts was significantly (p<0.35) lower than that (2790 g) of 27 infants of pure methadone addicts. Neonatal mortality rate per 1000 live births in IDAM was 33 and in the control group was 15Withdrawal symptoms were noted in 96% of IDAM....

A case of isolated hypoaldosteronism associated with chronic renal failure is reported. Potassium retention and hyperkalemia, sodium wasting, and inability to acidify the urine were all corrected by mineralocorticoid administration. Aldosterone secretion was 86.0 µg/day on a high sodium intake, 30.1 µg/day on a low sodium intake, and 36.2 µg/day after an angiotensin infusion. An important physiologic role is postulated for the hypersecretion of aldosterone usually seen in patients with chronic renal failure.