We present a case of intrahepatic cholestasis of pregnancy (ICP) treated with dexamethasone. Rapid elevation in transaminases was observed, beyond levels usually reported in this condition. The world literature is reviewed, with particular reference to a recently suggested treatment protocol using dexamethasone.

Summary: A case of hydrops fetalis resulting in neonatal death as a result of maternal Kell isoimmunization is presented, with a review of the literature and a suggested protocol for antenatal management of women with Kell antibodies.