Background Reliable and valid instruments are needed to estimate physical activity levels. The aim was to culturally adapt the “Rapid Assessment of Physical Activity” (RAPA) into Hungarian and to investigate the validity and reliability of this adapted version in the elderly over 50 years. Methods In our cross-sectional study 222 subjects were recruited in Hungary between December 2020 and January 2021(age 61.1 ± 7.9 years, 28% male). Criterion validity of RAPA and International Physical Activity Questionnaire (IPAQ)—Hungarian long version was tested by Spearman’s rank correlation. The examination of repeatability was based on a group of 32 people, and on the one-week test–retest reliability approach, and in addition to this during the statistical analysis intra-class correlation coefficient was calculated. To examine the sensitivity and specificity of the RAPA, negative and positive physical activity values were calculated from the results of the long version of the IPAQ and the RAPA. We tested 4 hypotheses (3 validity, 1 reliability). We considered acceptable validity and reliability if > 75% of hypotheses were confirmed. Results: All of the hypotheses (100%) were confirmed. Based on results of the validity testing of the newly adapted questionnaire was showed a moderate correlation between the examined measurement tools (R = 0.542, p < 0.001). The test–retest results of the questionnaire (N = 32, R = 0.988, p < 0.001) showed strong association. Conclusion RAPA showed fair to moderate validity and strong test–retest reliability similar to other studies. Based on our study’s results the RAPA is a valid and reliable questionnaire to measure the elderly Hungarian population’s physical activity.

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OBJECTIVES: Meningococcal serotype-B (MenB)-disease causes high case-fatality, severe sequelae, and a quality of life (QoL) loss in patients and their families. The objective is to quantify the loss in quality adjusted life years (QALYs) due to MenBdisease in Germany. METHODS: A hypothetical cohort consisting of the average number of age-specific MenB-disease cases in Germany between 2001 and 2015 was followed until their deaths. Probabilities and utilities of MenB-disease related sequelae and German utility-baseline norms were derived from the literature. A factor of 1.48 was applied to calculate spillover effects from patients to the QoL of their families and a factor of 1.09 for the parents' bereavement in case of death. A sensitivity analysis considered 3% annual discounting. RESULTS: The cohort's undiscounted QALY loss is 4,317.87 resulting in 12.58 QALYs per case (5.66 QALYs discounted). The highest QALY loss for an age-group can be found in the '1-4 (years old)' with 1,273.04, followed by a loss of 893.33 in infants '<1', i.e. 50% of the population QALY loss is attributable to these two groups. Age-groups with highest MenB carriage '15 to 19' and '20 to 24' amount to 22% of the total QALY loss. QALY loss per case in the age-groups '<1' and '1 to 4' is high with 16.42 and 16.14 contrasting to 10.61 and 9.53 in '15 to 19' and '20 to 24'. About 51% of the QALY loss is attributable to sequelae, 17.1% to spillover and 3.9% to parents' bereavement. CONCLUSIONS: The hypothetical cohort's QALY loss in Germany corresponds to 4,318 years in perfect health despite MenB being a rare disease. Comparing the high QALY loss per case with other diseases (e.g. Hepatitis C: undiscounted loss of 3.0 QALYs/case) and the QALY shortfall indicate the disease severity of MenB particularly among the youngest age groups, that could be protected through universal mass-vaccination.