AIM:This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers.METHOD:This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia.RESULTS:Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index.CONCLUSION:The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.

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