8 9Influenza viruses that infect humans are known to swiftly evolve over time. Influenza A virus 10 11 has a negative single-stranded RNA genome in eight segments. Pangenome analysis of twelve 12 13 strains of Influenza A viruses H1N1, H1N2, H2N2, H3N2, H5N1, H5N6, H7N2, H7N3, H7N7, 14 15 H7N9, H9N2, and H10N8 gave insight on the core genes that are conserved and accessory genes 16 that are specific for the strains. The proteins Neuraminidase, Matrix M1 and Nonstructural protein 17 1 were encoded by the core genes of segments 6, 7, and 8 respectively which proves that 20 they are conserved in almost all the strains of influenza. The 3Dimensional structures of the core 21 22 genes were interpreted by homology modeling and compared with corresponding Protein Data 23 24 Bank structures (4MWQ, IEA3, 2GX9). Among several anti-viral phytocompounds that were 25 26 virtually screened against the modeled and PDB target proteins, three molecules of Indian plant 27 Glycyrrhiza glabra had high scores and interactions. Compounds 2,4,4' Trihydrochalcone, 29 Davidigenin and Licoflavone B docked well with the Neuraminidase, Matrix protein M1 and 31 Nonstructural Protein NS1 respectively with good scores, minimized energy and interacted with 32 33 the active sites. The compounds obeyed Lipinski's Rule of five and exhibited drugability as well. 34 35Thus the present study focused on the drugable lead compounds from glabra that has inhibitory 36 37 activities against the viral attachment, replication and matrix structure.