ChemInform Abstract Reaction of antibiotic 2-methylfervenulone (MSD-92) (I) with nucleophiles is investigated. In each case (acid and base catalysis), the 4,4a-addition product is obtained. 4-Substituted o-phenylenediamines do not give the analogous addition reaction, but the alcohol used as the solvent reacts instead. The products have low antimicrobial activity.
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