In the Russian Federation, the proportion of children among all cases of new coronavirus infection is up to 8.6%. Mild forms are registered in 80% of cases, severe – 0.2%, as a rule, in children of the first year of life. The majority of deaths were recorded in children with an unfavorable background: 75% of those who died had one concomitant pathology, 45% – two or more. The problem of severe course and fatal outcomes from COVID-19 in children with comorbid pathology, for example, with various forms of leukemia, remains relevant. Severe infectious complications of bacterial nature are observed in 70–80% of sick children, viral and fungal genesis, respectively, in 4–12% and 18–20%. Myeloblastic leukemia is one of the factors that predispose to a severe course of COVID-19 and an unfavorable outcome. The article presents a clinical observation of the course of a critical form of a new coronavirus infection in a young child with acute myeloblastic leukemia. The layering of COVID-19 contributed to a sharp deterioration of the underlying disease. Despite the highly organized treatment process with the use of modern technologies, the child had a rapid deterioration of the condition with a fatal outcome. Key words: COVID-19, children, acute myeloblastic leukemia, pancytopenia, fatal outcome

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